{"id":659,"date":"2014-05-27T07:00:34","date_gmt":"2014-05-27T11:00:34","guid":{"rendered":"https:\/\/www.chaneyhealth.com\/healthtips\/?p=659"},"modified":"2014-05-26T16:35:52","modified_gmt":"2014-05-26T20:35:52","slug":"resveratrol-improve-blood-sugar-control","status":"publish","type":"post","link":"https:\/\/www.chaneyhealth.com\/healthtips\/resveratrol-improve-blood-sugar-control\/","title":{"rendered":"Does Resveratrol Improve Blood Sugar Control?"},"content":{"rendered":"

Is The Promise of Resveratrol True?
\n<\/strong><\/span><\/h1>\n

Author: Dr. Stephen Chaney<\/strong><\/h2>\n

\"blood<\/a>It was just a few years ago that resveratrol was the latest \u201cmiracle nutrient\u201d. It was featured on Dr. Oz and on 60 Minutes. It was hot! Today you see dueling headlines. The headlines one week proclaim the benefits of resveratrol. Next week\u2019s headlines say that it\u2019s all hype. What\u2019s a person to believe?<\/p>\n

Let me take you behind the headlines to look at the actual studies and answer some important questions.<\/p>\n

1)\u00a0\u00a0 \u00a0What do we actually know about the benefits of resveratrol?<\/p>\n

2)\u00a0\u00a0 \u00a0Is the evidence for beneficial effects of resveratrol where it should be considering the number of clinical studies that have been published?<\/p>\n

3)\u00a0\u00a0 \u00a0What additional studies need to be done before we can be sure that resveratrol is beneficial?<\/p>\n

4)\u00a0\u00a0 \u00a0Should you wait until we are absolutely certain resveratrol is beneficial, before you start using it? This is perhaps the most important question of all.<\/p>\n

To answer those questions, let\u2019s examine the study behind one of the latest headlines, namely: \u201cResveratrol Improves Blood Sugar Control in Diabetics\u201d. One of the promises of resveratrol has been that it might help diabetics and pre-diabetics who struggle with blood sugar control. However, this promise was based on animal studies. The study that generated the headlines in question was a meta-analysis of recently published human clinical trials in this area (Liu et al, Am. J. Clin. Nut., 2014, doi: 10.3945\/ajcn.113.082024).<\/p>\n

Does Resveratrol Improve Blood Sugar Control?<\/strong><\/span><\/h3>\n

The meta-analysis included 11 published placebo controlled double blind clinical studies looking at the effects of resveratrol supplementation on fasting blood sugar levels, insulin levels, hemoglobin A1c (a measure of blood sugar control) and insulin resistance (a measure closely associated with type 2 diabetes).<\/p>\n

A strength of this meta-analysis is the fact that it included 11 clinical studies. However, a weakness of this analysis is that these studies utilized a wide variety of resveratrol doses (10 mg\/day to 1 gram\/day), a wide variety of end points and both diabetic and non-diabetic patients. That means that there were only a few studies with common population groups, resveratrol doses, and end points.<\/p>\n

The conclusions of the study (and the headlines you may have seen) were that:<\/p>\n

\u2022\u00a0\u00a0 \u00a0Resveratrol appeared to improve blood sugar control (based on improvements in fasting blood sugar levels, insulin levels, hemoglobin A1c and insulin resistance) in diabetics.<\/p>\n

\u2022\u00a0\u00a0 \u00a0No consistent effect of resveratrol on blood sugar control was seen in non-diabetics.<\/p>\n

How Good Are These Studies?<\/strong><\/span><\/h3>\n

While these studies are very promising, they are bot definitive.\u00a0 There were only 3 published clinical studies in diabetics. While all 3 of the studies showed a positive effect of resveratrol supplementation:<\/p>\n

\u2022\u00a0\u00a0 \u00a0The doses used were different in each study (ranging from 10 mg\/day to 1 gram\/day)<\/p>\n

\u2022\u00a0\u00a0 \u00a0Each study measured different end points (one measured blood glucose, insulin levels, hemoglobin A1c and insulin resistance, one measured blood glucose and hemoglobin A1c and the third measured insulin resistance).<\/p>\n

As a research scientist I would like to see more studies done at comparable doses and measuring the same end points \u2013 we scientists always want more studies.<\/p>\n

Similarly, there was not enough consistency in the studies with non-diabetics to draw a firm conclusion. (3 were with obese patients, 3 were with patients with cardiovascular disease, 1 was with patients with metabolic syndrome and 1 was with perfectly healthy subjects.)<\/p>\n

If you really wanted to see if something like resveratrol helps non-diabetics with blood sugar control, you would want to start with people who are already experiencing some difficulties with blood sugar control (pre-diabetics or patients with metabolic syndrome) and follow them for a couple of years to see if resveratrol reduces the number of them who become diabetic.<\/p>\n

Are The Headlines Just Hype?<\/strong><\/span><\/h3>\n

\"Newspaper<\/a>Does that mean that the blood sugar benefits of resveratrol are just hype? The answer is no. There is a difference between \u201cvery promising, but not yet definitive\u201d and \u201chype\u201d. We shouldn\u2019t be surprised that human studies on the health benefits of resveratrol are not yet definitive. Science moves slowly. It often takes decades of scientific research before promising concepts are widely accepted by the scientific community.<\/p>\n

When a research area is as young as this one, we sometimes need to go beyond the clinical studies and look at the totality of evidence. In this case:<\/p>\n

\u2022\u00a0\u00a0 \u00a0In mice resveratrol exerts its beneficial effects by turning on a specific anti-aging gene called SIRT1 (Cell Metabolism, 15: 675-690, 2012). In humans, resveratrol appears to activate the same genetic pathways as in mice (Journal of Clinical Endocrinology & Metabolism, 96: 1409-1414, 2011).<\/p>\n

\u2022\u00a0\u00a0 \u00a0In obese mice resveratrol improves markers of blood sugar control (Nature, 444: 337-342, 2006). Published clinical studies in diabetic humans also show improvements in blood sugar control (Journal of Clinical Nutrition, 2014, doi: 10.3945\/ajcn.113.082024).<\/p>\n

So while more and better clinical studies are needed to be absolutely certain that resveratrol helps improve blood sugar control, the evidence supporting that effect is substantial.<\/p>\n

What Should You Do?<\/strong><\/span><\/h3>\n

The ONLY important question for each of you is probably: \u201cShould I wait a decade or two until we are absolutely sure about the health benefits of resveratrol before I take a resveratrol supplement?\u201d That question is ultimately yours to answer. It\u2019s all about benefits and risk.<\/p>\n

Benefits<\/strong><\/span> – In animal studies resveratrol clearly improves blood sugar control. The human clinical studies published to date are consistent with the animal studies.<\/p>\n

Risk<\/span><\/strong> – Current data suggest that resveratrol appears to be safe, even at high doses. For example, one recent study indicated that up to 5 gm\/day is safe (Cancer Epidemiology BioMarkers & Prevention, volume 16:1246-1262, 2007), but I wouldn\u2019t personally recommend exceeding 100-200 mg\/day.<\/p>\n

The Bottom Line:<\/strong><\/span><\/h3>\n

1)\u00a0\u00a0\u00a0\u00a0 Don\u2019t get too excited about the headlines suggesting that resveratrol might help improve blood sugar control in diabetics. The few human clinical studies that have been published to date are consistent with previous animal studies. That is very promising, but more studies are needed before we can be absolutely confident that resveratrol supplementation is beneficial for diabetics.<\/p>\n

2)\u00a0\u00a0\u00a0\u00a0 Similarly, don\u2019t be discouraged by the headlines suggesting that resveratrol does not help with blood sugar control in non-diabetics. Those results are preliminary as well.<\/p>\n

3)\u00a0\u00a0\u00a0\u00a0 That doesn\u2019t mean that the headlines are just hype. It takes decades to accumulate definitive proof that any kind of food or nutrient offers proven benefits, and the bulk of human clinical research on reveratrol has occurred in the last couple of years. We are exactly where we should expect to be at this point in time.<\/p>\n

4)\u00a0\u00a0\u00a0\u00a0 With something as promising as resveratrol, the real question becomes whether you can afford to wait a decade or two until you know whether the potential benefits have been definitely proven. That question is up to you. On the plus side, current data suggest that resveratrol is highly promising for blood sugar control. In addition, resveratrol appears to be safe, even at high doses, but I wouldn\u2019t personally recommend exceeding 100-200 mg\/day.<\/p>\n

5)\u00a0\u00a0\u00a0\u00a0 We already know that weight control, exercise and a healthy diet improve blood sugar control. You should think of resveratrol as something you may wish to add to a healthy lifestyle, not as a substitute for a healthy lifestyle.<\/p>\n

6)\u00a0\u00a0\u00a0\u00a0 If you are diabetic and decide to try a resveratrol supplement, be sure to work with your physician so they can modify your dose of insulin or blood sugar medication as necessary.<\/p>\n

7)\u00a0\u00a0\u00a0\u00a0 Finally, you may be asking whether resveratrol supplements are even necessary. Can\u2019t you just get all the resveratrol you need from a glass or two of red wine? Stay tuned. I\u2019ll have the answer to that question in a couple of weeks.<\/p>\n

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Is The Promise of Resveratrol True? Author: Dr. Stephen Chaney It was just a few years ago that resveratrol was the latest \u201cmiracle nutrient\u201d. It was featured on Dr. Oz and on 60 Minutes. It was hot! Today you see dueling headlines. The headlines one week proclaim the benefits of resveratrol. Next week\u2019s headlines say … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19,4,129],"tags":[348,25,349,107,108],"class_list":["post-659","post","type-post","status-publish","format-standard","hentry","category-food-and-health","category-issues","category-supplements-and-health","tag-blood-sugar","tag-diabetes","tag-insulin-resistance","tag-red-wine","tag-resveratrol"],"yoast_head":"\nDoes Resveratrol Improve Blood Sugar Control? - Health Tips From The Professor<\/title>\n<meta name=\"description\" content=\"Animal studies have suggested that resveratrol can improve blood sugar control. 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