{"id":5268,"date":"2025-10-14T07:00:59","date_gmt":"2025-10-14T11:00:59","guid":{"rendered":"https:\/\/www.chaneyhealth.com\/healthtips\/?p=5268"},"modified":"2025-08-30T22:57:35","modified_gmt":"2025-08-31T02:57:35","slug":"can-protein-supplements-increase-glp-1","status":"publish","type":"post","link":"https:\/\/www.chaneyhealth.com\/healthtips\/can-protein-supplements-increase-glp-1\/","title":{"rendered":"Can Protein Supplements Increase GLP-1?"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"color: #008000;\"><strong>What Is GLP-1 And What Does It Do?<\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><strong>Author: Dr. Stephen Chaney<\/strong><\/p>\n<p><a href=\"https:\/\/www.chaneyhealth.com\/healthtips\/are-glp-1-users-getting-enough-nutrients\/glp-1_depositphotos_768429820_l\/#main\" rel=\"attachment wp-att-5262\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-5262\" src=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/GLP-1_Depositphotos_768429820_L-300x193.jpg\" alt=\"\" width=\"300\" height=\"193\" srcset=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/GLP-1_Depositphotos_768429820_L-300x193.jpg 300w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/GLP-1_Depositphotos_768429820_L-1024x658.jpg 1024w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/GLP-1_Depositphotos_768429820_L-768x494.jpg 768w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/GLP-1_Depositphotos_768429820_L-1536x988.jpg 1536w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/GLP-1_Depositphotos_768429820_L.jpg 2000w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>I don\u2019t need to tell you that GLP-1 (glucagon-like peptide 1) drugs are all the rage. Total spending on GLP-1 drugs in the United States exceeded $71 billion in 2023, a 500% increase in just 5 years. There are 15 million Americans on GLP-1 drugs at any one time. And most of this increase has been driven by the weight-loss market.<\/p>\n<p>Let me be clear. These drugs work. For people with poorly controlled type 2 diabetes or severe obesity-related health issues, they can be a godsend. But like any \u201cquick fix\u201d weight loss drugs they are overprescribed.<\/p>\n<p>And when you have millions of people taking a drug, you need to take a serious look at side effects. The most frequent side effects are:<\/p>\n<ul>\n<li>Nausea<\/li>\n<li>Vomiting<\/li>\n<li>Diarrhea<\/li>\n<li>Constipation<\/li>\n<li>Increased heart rate.<\/li>\n<li>Hypoglycemia<\/li>\n<li>Allergic reactions<\/li>\n<\/ul>\n<p>These are side effects that aren\u2019t life threatening and are easily detected. When someone experiences these side effects, they usually give their doctor a call, and their doctor either takes them off the drug or modifies the dosage.<\/p>\n<p>However, more recent studies have identified two additional side effects that are much more troubling.<\/p>\n<ul>\n<li>The first is depression, anxiety, and suicidal thoughts.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>These are symptoms that many patients may not associate with the drug, especially if they already have these tendencies.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>And the consequences can be life threatening. There have already been reports of suicides of people on GLP-1 medications.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li>The second is loss of muscle mass.<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>This is a particular concern for seniors who struggle to maintain muscle mass as they age.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>And this is a silent symptom. Most seniors don\u2019t realize they are losing muscle mass until it significantly affects their quality of life.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>And, of course, the biggest drawback of GLP-1 drugs is that they are only a temporary fix. Unless someone changes their lifestyle, the weight comes roaring back as soon as they quit using GLP-1.<\/p>\n<p>So. It\u2019s no wonder some people are asking whether it is possible to increase their GLP-1 levels naturally without the side effects associated with GLP-1 drugs. I will discuss this below, but first I should review what GLP-1 is and what it does.<\/p>\n<h2 style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong>What Is GLP-1 And What Does It Do?<\/strong><strong>\u00a0<\/strong><\/span><\/h2>\n<p><a href=\"https:\/\/www.chaneyhealth.com\/healthtips\/?attachment_id=5269#main\" rel=\"attachment wp-att-5269\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-5269\" src=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Yin-Yang-Depositphotos_231022374_L-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Yin-Yang-Depositphotos_231022374_L-300x300.jpg 300w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Yin-Yang-Depositphotos_231022374_L-1024x1024.jpg 1024w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Yin-Yang-Depositphotos_231022374_L-150x150.jpg 150w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Yin-Yang-Depositphotos_231022374_L-768x768.jpg 768w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Yin-Yang-Depositphotos_231022374_L-1536x1536.jpg 1536w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Yin-Yang-Depositphotos_231022374_L.jpg 2000w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Let me start by reviewing the hormones insulin and glucagon to create a proper perspective for understanding the role of GLP-1.<\/p>\n<p><span style=\"color: #3366ff;\"><strong>Insulin:<\/strong><\/span> Almost everyone has heard of insulin. It is released by the pancreas whenever we eat, and blood sugar levels start to rise. Its role is to lower blood sugar levels.<\/p>\n<p><span style=\"color: #3366ff;\"><strong>Glucagon<\/strong>:<\/span> Glucagon is less well known, but you can think of it as the Yin to insulin\u2019s Yang. It is released by the pancreas when blood sugar levels fall and continues to be present until the next meal. Its role is to increase blood sugar levels and make sure that our cells get the food they need until the next meal.<\/p>\n<p><span style=\"color: #3366ff;\"><strong>GLP-1<\/strong>:<\/span> GLP-1 stands for glucagon-like peptide 1. With a name like that, you might expect GLP-1 to have significant sequence homology with glucagon, bind to the same receptors, and have a similar effect on our metabolism. You would be wrong!<\/p>\n<p>Both peptide hormones are derived from a much larger peptide called proglucagon. This is the only way that GLP-1 is \u201clike\u201d glucagon.<\/p>\n<p>One portion of proglucagon is processed to give glucagon in pancreatic alpha cells. Another portion is processed to give GLP-1 in intestinal L cells. [L cells are endocrine (hormone producing cells) found in the intestinal mucosa.] There is very little sequence or structural homology between glucagon and GLP-1.<\/p>\n<p>Their function is also very different. You can think of GLP-1 as a partner to insulin. It is released by intestinal L cells in response to the presence of nutrients (primarily protein, fat, and carbohydrate) in the intestine. It binds to GLP-1 receptors on the\u2026<\/p>\n<ul>\n<li>Pancreas to stimulate insulin release and inhibit glucagon release. This is why it helps type 2 diabetics control their blood sugar levels.<\/li>\n<\/ul>\n<ul>\n<li>Stomach to reduce the rate of gastric emptying. This prolongs the feeling of fullness after each meal.<\/li>\n<\/ul>\n<ul>\n<li>Small intestine to reduce gut motility, which increases transit time through the small intestine. This also prolongs the feeling of fullness after a meal. But it can also lead to gastrointestinal side effects.<\/li>\n<\/ul>\n<ul>\n<li>Brain to turn down your \u201cappestat\u201d. This reduces feelings of hunger between meals. But at high doses, it can affect the brain in negative ways (anxiety, depression, and suicidal thoughts).<\/li>\n<\/ul>\n<h2 style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong>Can Protein Supplements Increase GLP-1?<\/strong><strong>\u00a0<\/strong><\/span><\/h2>\n<p><a href=\"https:\/\/www.chaneyhealth.com\/healthtips\/which-foods-affect-stroke-risk\/beautiful-woman-with-questioning-expression-and-question-marks-a\/#main\" rel=\"attachment wp-att-3863\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-3863\" src=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2020\/03\/Questioning-Woman-Depositphotos_16018497_s-2015-300x223.jpg\" alt=\"Questioning Woman\" width=\"300\" height=\"223\" srcset=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2020\/03\/Questioning-Woman-Depositphotos_16018497_s-2015-300x223.jpg 300w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2020\/03\/Questioning-Woman-Depositphotos_16018497_s-2015.jpg 500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>You may be wondering, \u201cIs it possible to increase GLP-1 levels naturally without side effects?\u201d The answer is clearly, \u201cYes\u201d. Every time you eat a meal, your GLP-1 levels increase naturally.<\/p>\n<p>When you eat a meal, GLP-1 levels rise within 10 minutes and remain elevated for 1-2 hours. Then enzymes present in the bloodstream digest GLP-1 and it disappears. <span style=\"color: #3366ff;\"><strong>This is the way nature intended<\/strong>.<\/span> There are no side effects to the natural rise and fall of GLP-1 after a meal.<\/p>\n<p>And protein appears to play an important role in this process. High-protein meals result in higher and more prolonged GLP-1 levels than high-fat or high-carbohydrate meals. That\u2019s because protein is digested to amino acids in the intestine. And some of those amino acids bind to receptors in intestinal L-cells and stimulate GLP-1 release.<\/p>\n<p>You may be wondering what this has to do with protein supplements. Theoretically, protein supplements should offer the same benefit as a high-protein meal with fewer calories.<\/p>\n<p>This hypothesis has been tested with a few protein supplements, and they have been shown to increase GLP-1 levels naturally. And, based on the limited data available, it appears that the increase in GLP-1 is proportional to the protein content of the supplement.<\/p>\n<p>So, it appears that the answer I posed at the beginning of this article is,<\/p>\n<ul>\n<li>Yes, it appears that protein supplements can increase protein levels naturally.<\/li>\n<\/ul>\n<ul>\n<li>And it appears that the higher the protein content of the supplement, the greater the increase in GLP-1 levels.<\/li>\n<\/ul>\n<p>However, there are many variations in the formulation of protein supplements, and we don\u2019t know how these variations influence the effect of protein supplements on GLP-1 levels. Therefore,<\/p>\n<ul>\n<li>We can\u2019t yet say that all protein supplements increase GLP-1 levels equally.<\/li>\n<\/ul>\n<ul>\n<li>When choosing a protein supplement, you should ask for clinical studies with their product showing it increases GLP-1 levels.<\/li>\n<\/ul>\n<h2 style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong>What Does This Mean For You?<\/strong><\/span><\/h2>\n<p><a href=\"https:\/\/www.chaneyhealth.com\/healthtips\/?attachment_id=5270#main\" rel=\"attachment wp-att-5270\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-5270\" src=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Mother-Nature-Depositphotos_32937889_s-2015-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Mother-Nature-Depositphotos_32937889_s-2015-300x300.jpg 300w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Mother-Nature-Depositphotos_32937889_s-2015-150x150.jpg 150w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2025\/08\/Mother-Nature-Depositphotos_32937889_s-2015.jpg 500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>If you can raise your GLP-1 levels naturally with high-protein meals and protein supplements, you might be asking, \u201cWhat makes the GLP-1 drugs different?\u201d To understand the answer to that question, you first need to know what GLP-1 drugs are.<\/p>\n<ul>\n<li>GLP-1 drugs mimic the natural GLP-1 peptide.<\/li>\n<\/ul>\n<ul>\n<li>However, GLP-1 drugs have been genetically modified to make them resistant to enzymatic digestion. They can stay in the bloodstream for up to 24 hours.<\/li>\n<\/ul>\n<p>This is what makes them so effective as weight loss drugs. But <strong><span style=\"color: #3366ff;\">it\u2019s not nice to fool with mother nature<\/span>.<\/strong> This is also why they have side effects.<\/p>\n<p>And let\u2019s remember that while GLP-1 drugs are effective, you will need to take them for the rest of your life unless you change your diet and lifestyle. And with long-term usage of the drugs, you are likely to experience one or more of their side effects at some point.<\/p>\n<p>So, if you are willing to change your diet and lifestyle, it may be worthwhile looking at increasing your GLP-1 levels naturally. The effect may not be as strong as with the GLP-1 drugs, but it may help you suppress your appetite enough to successfully implement your lifestyle changes. You have lots of options.<\/p>\n<ul>\n<li>Every time you eat a meal your GLP-1 levels increase. And the bigger the meal, the bigger the increase. But the bigger the meal, the greater the calories. So, that\u2019s not an optimal way to increase GLP-1 levels.<\/li>\n<\/ul>\n<ul>\n<li>That\u2019s where protein supplements come in.<\/li>\n<\/ul>\n<ul>\n<li>And since you are trying to maximize GLP-1 levels with the minimum calories, I recommend a 20\u201340-gram protein supplement with a minimum of carbohydrate and fat. Just be sure the manufacturer has done a clinical study to demonstrate their protein supplement raises GLP-1 levels.<\/li>\n<\/ul>\n<h2 style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong>The Bottom Line<\/strong><\/span><\/h2>\n<p>In this article I asked the question, \u201cCan protein supplements increase GLP-1 levels naturally without the side effects of GLP-1 drugs?\u201d The answer is, \u201cYes\u201d. In this article I tell you:<\/p>\n<ul>\n<li>What GLP-1 is and what it does.<\/li>\n<\/ul>\n<ul>\n<li>Why GLP-1 drugs have side effects.<\/li>\n<\/ul>\n<ul>\n<li>How protein supplements can raise your GLP-1 levels naturally without the side effects of GLP-1 drugs.<\/li>\n<\/ul>\n<p>For more details read the article above.<\/p>\n<p><em>These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.<\/em><\/p>\n<p><em>\u00a0______________________________________________________________________________<\/em><\/p>\n<p>My posts and \u201cHealth Tips From the Professor\u201d articles carefully avoid claims about any brand of supplement or manufacturer of supplements. However, I am often asked by representatives of supplement companies if they can share them with their customers.<\/p>\n<p>My answer is, \u201cYes, as long as you share only the article without any additions or alterations. In particular, you should avoid adding any mention of your company or your company\u2019s products. If you were to do that, you could be making what the FTC and FDA consider a \u201cmisleading health claim\u201d that could result in legal action against you and the company you represent.<\/p>\n<p>For more detail about FTC regulations for health claims, see this link.<\/p>\n<p><a href=\"https:\/\/www.ftc.gov\/business-guidance\/resources\/health-products-compliance-guidance\"><span style=\"color: #0000ff;\">https:\/\/www.ftc.gov\/business-guidance\/resources\/health-products-compliance-guidance<\/span><\/a><\/p>\n<p><strong>\u00a0_______________________________________________________________________<\/strong><\/p>\n<h2 style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong>About The Author<\/strong><strong>\u00a0<\/strong><\/span><\/h2>\n<p><a href=\"https:\/\/www.chaneyhealth.com\/healthtips\/what-kind-of-protein-is-best-for-strength\/chaney-suzanne-steve-11-21-15\/#main\" rel=\"attachment wp-att-4932\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-4932\" src=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2024\/02\/Chaney-Suzanne-Steve-11-21-15-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2024\/02\/Chaney-Suzanne-Steve-11-21-15-300x200.jpg 300w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2024\/02\/Chaney-Suzanne-Steve-11-21-15-768x512.jpg 768w, https:\/\/www.chaneyhealth.com\/healthtips\/wp-content\/uploads\/2024\/02\/Chaney-Suzanne-Steve-11-21-15.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Dr. Chaney has a BS in Chemistry from Duke University and a PhD in Biochemistry from UCLA. He is Professor Emeritus from the University of North Carolina where he taught biochemistry and nutrition to medical and dental students for 40 years.<\/p>\n<p>Dr. Chaney won numerous teaching awards at UNC, including the Academy of Educators \u201cExcellence in Teaching Lifetime Achievement Award\u201d.<\/p>\n<p>Dr Chaney also ran an active cancer research program at UNC and published over 100 scientific articles and reviews in peer-reviewed scientific journals. In addition, he authored two chapters on nutrition in one of the leading biochemistry text books for medical students.<\/p>\n<p>Since retiring from the University of North Carolina, he has been writing a weekly health blog called &#8220;Health Tips From the Professor&#8221;. He has also written two best-selling books, &#8220;Slaying the Food Myths&#8221; and &#8220;Slaying the Supplement Myths&#8221;. And most recently he has created an online lifestyle change course, &#8220;Create Your Personal Health Zone&#8221;. For more information visit <a href=\"https:\/\/chaneyhealth.com\"><span style=\"color: #0000ff;\">https:\/\/chaneyhealth.com<\/span><\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>For the past 53 years Dr. Chaney and his wife Suzanne have been helping people improve their health holistically through a combination of good diet, exercise, weight control and appropriate supplementation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What Is GLP-1 And What Does It Do? Author: Dr. Stephen Chaney I don\u2019t need to tell you that GLP-1 (glucagon-like peptide 1) drugs are all the rage. Total spending on GLP-1 drugs in the United States exceeded $71 billion in 2023, a 500% increase in just 5 years. There are 15 million Americans on &#8230; <a title=\"Can Protein Supplements Increase GLP-1?\" class=\"read-more\" href=\"https:\/\/www.chaneyhealth.com\/healthtips\/can-protein-supplements-increase-glp-1\/\" aria-label=\"Read more about Can Protein Supplements Increase GLP-1?\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1285,1149,1243,1,376],"tags":[1201,970,45,670,1187,233],"class_list":["post-5268","post","type-post","status-publish","format-standard","hentry","category-glp-1","category-protein","category-protein-supplements","category-uncategorized","category-weight-loss","tag-glp-1","tag-high-protein","tag-high-protein-diets","tag-protein","tag-protein-supplement","tag-weight-loss"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can Protein Supplements Increase GLP-1? - Health Tips From The Professor<\/title>\n<meta name=\"description\" content=\"Glp-1 drugs are expensive and have serious side effects. 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